CHRONIC UNCONJUGATED HYPERBILIRUBINEMIA WITHOUT OVERT SIGNS OF HEMOLYSIS IN ADOLESCENTS AND ADULTS*
نویسندگان
چکیده
منابع مشابه
Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults.
The syndrome of chronic unconj ugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults has been variously termed cholemie simple familiale (Gilbert's disease) (1), icterus intermittens juvenilis (2), hereditary nonhemolytic bilirubinemia (3), familial nonhemolytic jaundice (4), physiologic hyperbilirubinemia (5), and constitutional hepatic dysfunction (6). These ter...
متن کاملPharmacological therapies for unconjugated hyperbilirubinemia.
Severe unconjugated hyperbilirubinemia, seen mainly in neonates, may cause kernicterus and death. Conventional treatment for severe unconjugated hyperbilirubinemia consists of phototherapy and exchange transfusion. Phototherapy, however, has several known disadvantages while exchange transfusion is associated with a significant morbidity, and even mortality. These harmful effects indicate the n...
متن کاملUrinary excretion of biopyrrin in unconjugated hyperbilirubinemia
Biopyrrin is an oxidative metabolite of bilirubin. Biopyrrin is a tripyrrol moiety of bilirubin, including two regioisomers (biotripyrrin-a, 1,14,15,17tetrahydro-2,7,13-trimethyl-1,14-deoxy-3-vinyl-16Htripyrrin-8,12-dipropionic acid and biotripyrrin-b, 1,14,15,17-tetrahydro-3,7,13-trimethyl-1,14-deoxy2-vinyl-16H-tripyrrin-8,12-dipropionic acid: Fig. 1). For many years, bilirubin was regarded as...
متن کاملEffect of hemolysis and hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient neonates
Objective: Recently, the role of hemolysis in the pathophysiology of hyperbilirubinemia in glucose-6phosphate dehydrogenase (G6PD) deficient neonates has been questioned and decreased bilirubin conjugation has been suggested. We conducted a study to evaluate the effect of hemolysis on these neonates at the 17-Shahrivar Children Hospital in Rasht. Methods: In this cross-sectional s...
متن کاملClofibrate for unconjugated hyperbilirubinemia in neonates: a systematic review.
OBJECTIVE To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates. METHODS A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated hyperbilirubinemia. We followed the guidelines from the Cochrane review group and the PRISMA statemen...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1962
ISSN: 0021-9738
DOI: 10.1172/jci104682